Metformin appeared to slow prostate cancer growth: study

Xinhua News Agency – CEIS

04-03-12

Metformin appeared to slow prostate cancer growth: study

WASHINGTON, April 2 (Xinhua) — The use of metformin in men with prostate cancer before prostatectomy helped to reduce certain metabolic parameters and slow the growth rate of the cancer, according to the results of a phase II study.

Anthony Joshua, staff medical oncologist at the Princess Margaret Hospital in Canada, presented the data at the American Association for Cancer Research Annual Meeting 2012, held in Chicago on March 31 – April 4.

Metformin is the most commonly prescribed medication for diabetes. Prior laboratory research has suggested that metformin may also help to improve prognosis in patients with prostate cancer by slowing the growth of the cancerous cells.

To follow up on the laboratory clues, the researchers evaluated 22 men with confirmed prostate cancer who had been assigned up to 500 mg of metformin three times a day prior to undergoing prostatectomy.

“This gave us the ability to compare what the prostate cancer looked like when it was first diagnosed to what it looked like when the prostate cancer was removed from the body,” said Joshua. “We were able to directly measure the effect of metformin on the prostate cancer.”

Patients were assigned metformin for a median duration of 41 days. During that time, none of the men reported grade three adverse events, and all of them underwent prostatectomy with no adverse effect related to use of metformin.

The researchers found that metformin significantly reduced fasting glucose, insulin growth factor-1, body mass index and waist- to-hip ratio.

In addition, “although these are preliminary results, metformin appeared to reduce the growth rate of prostate cancer in a proportion of men,” Joshua said. “Also, it appeared to reduce one of the main growth pathways that may have contributed to the overall growth of the tumor.”

These results may have implications for men with prostate cancer who also have diabetes or early undiagnosed diabetes and for men with prostate cancer whose tumors have characteristics that make them sensitive to metformin, according to Joshua.

(c) 2012 Xinhua News Agency – CEIS. Provided by ProQuest LLC. All rights Reserved.

Copyright Xinhua News Agency – CEIS 2012

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Caffeine, exercise may be protective against skin cancer: study

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Caffeine, exercise may be protective against skin cancer: study

Xinhua News Agency – CEIS

04-09-12

Caffeine, exercise may be protective against skin cancer: study

WASHINGTON, April 4 (Xinhua) — The combined effects of exercise plus caffeine consumption may be able to ward off skin cancer, U.S. researchers reported Wednesday.

The findings were presented at the American Association for Cancer Research Annual Meeting 2012, held in Chicago on March 31- April 4.

The researchers evaluated the effects of caffeine and exercise on mice at high risk for developing skin cancer. Results showed that mice that took a dose of caffeine and exercised with a running wheel experienced 62 percent fewer skin tumors. The volume of tumors also decreased by 85 percent compared with the mice that did not consume caffeine or exercise.

Positive effects were found with either caffeine or exercise alone, but to a lesser extent. Researchers observed a 27 percent reduction in tumors in caffeine-only mice and a 61 percent reduction in tumor size. In the exercise-only mice, researchers found that tumor activity decreased by 35 percent and tumor volume decreased by 70 percent.

“We found that this combination treatment can decrease sunlight- caused skin cancer formation in a mouse model,” said Yao-Ping Lu, associate research professor at the Rutgers University. “I believe we may extrapolate these findings to humans and anticipate that we would benefit from these combination treatments as well.”

(c) 2012 Xinhua News Agency – CEIS. Provided by ProQuest LLC. All rights Reserved.

Copyright Xinhua News Agency – CEIS 2012

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Many aren’t doing enough to control hypertension

Allison Griffin
Montgomery Advertiser, Ala.

02-07-12

Feb. 07–HYPERTENSION — high blood pressure — was a primary or contributing cause of death for 326,000 Americans in 2006, according to the Centers for Disease Control and Prevention. It puts us at risk for heart disease and stroke, the first and third leading causes of death in the U.S.

Despite the statistics, high blood pressure can be controlled, and it is not a death sentence. But as with other chronic conditions, awareness of it, and compliance with a doctor’s instructions and/or medication to treat it, is crucial to its control.

About one in three Americans — 31 percent — has high blood pressure. But one local cardiologist thinks there’s probably a percentage who aren’t even aware they have it.

Even more alarming, Dr. Paul Moore said, is that many who have been diagnosed with it aren’t controlling it.

“Part of it is noncompliance on the patient’s part,” said Moore, who is part of the Montgomery Cardiovascular Associates practice. “They can’t afford the medications, they don’t like taking medications, or they don’t like the way they make them feel.”

But another part of it is that physicians in general are perhaps not as attentive to high blood pressure as they should be, Moore said.

“There are so many other things you have to take care of in patients, and sometimes hypertension doesn’t rise to the surface.”

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps the blood. If this pressure rises and stays high over time, it can damage and scar the body’s arteries.

It’s expressed as two numbers. The first, or systolic, represents the pressure in your blood vessels when the heart beats. The second, or diastolic, represents the pressure in the vessels when the heart rests between beats.

Normal is considered less than 120 over 80 millimeters of mercury. At risk is 120 to 139 over 80 to 89, and high is 140 over 90 or higher.

Most hypertension, called essential hypertension, has no specific cause, Moore said, though genetics play a real role. And most Americans are aware that too much salt in the diet can lead to fluid retention, which increases blood pressure.

Among the other risk factors are age, race (hypertension is more common in African Americans), being overweight, lack of physical activity, tobacco use, low potassium intake, excessive alcohol and stress.

Know your numbers

Because hypertension often has no signs or symptoms, the only way to find out if you have it is to have your blood pressure taken by a health care professional.

Some tips to follow before having a reading taken:

Don’t drink coffee or smoke cigarettes 30 minutes before a reading.

Before the test, sit for five minutes with your back supported and your feet flat on the ground.

Wear short sleeves, or if you must wear long sleeves, wear a shirt made of a light, thin material.

Go to the bathroom prior to the reading; a full bladder can change the reading.

Have two readings taken, at least two minutes apart, and average the results.

Be sure to ask the nurse to tell you the blood pressure reading, in numbers.

If you are diagnosed with hypertension, your physician may suggest purchasing a small blood pressure monitor to use at home, to keep regular track of your readings between visits. Monitors start at about $35 and go up from there.

“That gives me a better impression than when they’re in the doctor’s office,” Moore said, noting that the so-called “white coat hypertension” — when a person’s blood pressure is elevated because he or she is in the doctor’s office — is a real factor.

If you check your blood pressure at home, it’s a good idea to take your at-home machine to the doctor’s office on your next trip to have the staff compare its reading to their reading, said Susan Mann, registered dietitian and instructor with Baptist’s Center for Diabetes/Nutrition Education.

Check your foods

Mann teaches classes on hypertension and its management, focusing on the dietary factors that contribute to it — especially sodium.

Sodium lurks in most processed and commercially prepared foods, even ones that you might not suspect. Cheeses and lunch meats, for example, can be packed with sodium.

The current recommendation is no more than 2,300 milligrams a day, equal to about one teaspoon of table salt. But the daily recommendation is for all sodium — not just what you add at the table.

Read labels carefully to check the sodium amount, and note the serving size. But the best way to lower your sodium intake is to prepare meals at home, using fresh ingredients. That way, you control the amount of seasonings.

Salt is a learned taste, Mann said, and if you practice cutting back on it, your tastes will adapt.

If you prefer to follow a prescribed meal plan, one of the best for lowering blood pressure is the Dietary Approaches to Stop Hypertension, or DASH, eating plan, developed by the U.S. Department of Health and Human Services.

U.S. News and World Report has ranked the DASH diet as one of the top commercially available plans on the market, thanks to its nutritional requirements, safety and effectiveness.

“DASH has a lot of fruits and vegetables that are high in nutrients like potassium, magnesium and fiber, and potassium has been associated with lowering blood pressure,” said Catherine Loria, nutritional epidemiologist with the National Heart, Lung and Blood Institute.

Loria said DASH also focuses on lean meats, nuts, seeds and legumes and whole grains.

It was originally developed to test the effectiveness of these micronutrients in controlling blood pressure, and if foods in combination could lower blood pressure, Loria said.

It offers the choice between two levels of sodium consumption — 2,300 and 1,500 milligrams per day.

Since its inception more than 15 years ago, it has earned the respect of physicians and dietitians.

“I give the DASH diet to almost all my patients,” Moore said. “I think it’s very legitimate.”

Loria said DASH also helps with portion sizes, which is confusing for some dieters. “The good thing about DASH is that it tells you what a serving size should be.”

Additional sources: American Heart Association, National Heart, Lung and Blood Institute, Baptist Health

___

(c)2012 the Montgomery Advertiser (Montgomery, Ala.)

Visit the Montgomery Advertiser (Montgomery, Ala.) at www.montgomeryadvertiser.com

Distributed by MCT Information Services

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Anti-cancer drug for women weakens bone density

Agence France-Presse

02-07-12

A drug tapped for widespread use to prevent breast cancer in post-menopausal women also accelerates loss of bone density, thus potentially boosting the risk of fractures, a study published on Tuesday said.

6Exemestane — brand name Aromasin — is part of a drug class called aromatase inhibitors, which lower levels of the oestrogen that some breast cancers need in order to grow.

Canadian bone specialists took a look at a group of patients who had taken part in a study into the effectiveness of exemestane among 4,500 healthy women with a worrying family history of breast cancer.

Overall, the big study showed that the drug was highly effective, reducing the risk of breast cancer by almost two-thirds.

The bone sub-study looked at 351 women who had been taking either exemestane or a dummy lookalike pill and whose bone density was measured with hi-tech scanners.

After two years, women taking exemestane had a high loss of bone density at a common fracture point in the wrist called the distal radius, and also at the lower end of the tibia, compared with their counterparts on placebo.

The exemestane users also had an eight-percent decline in the thickness of cortical bone, which comprises the protective outer shell of the bones.

That finding in particular is worrying because nearly four out of every five fractures in old age occur in cortical bone. These accidents are a huge source of disability.

“Women considering exemestane for the primary prevention of breast cancer should weigh their individual risks and benefits,” says the study, headed by Angela Cheung of the University Health Network in Toronto.

“For women taking exemestane, regular bone monitoring plus adequate calcium and vitamin D supplementation are important.”

The paper is published online by the journal The Lancet Oncology.

ri/mh/hmn

COPYRIGHT 2002 Agence France-Presse. All rights reserved.

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Lifestyle blamed for 40 percent of cancers

United Press International

01-25-12

Forty percent of cancers in women and 45 percent in men could be prevented by a healthier lifestyle, British researchers say.

A Cancer Research UK report found more than 100,000 cancers each year in Britain are caused by four lifestyle factors — smoking, unhealthy diet, alcohol and being overweight — and the number rises to around 134,000 a year when 14 lifestyle and environmental factors are taken into account, the Guardian reported.

The research showed that in Britain:

– Smoking accounts for 23 percent of all cancers in men and 15.6 percent in women. It causes lung cancer as well as bladder, kidney, pancreatic and cervical cancer.

– One-in-25 cancers is linked to work-related exposure to chemicals or asbestos, while one in 33 is linked to infections, such as the human papillomavirus, which causes most cases of cervical cancer.

– Thirty-four percent of cancers in 2010, 106,845, were linked to smoking, diet, drinking alcohol and excess weight.

In men, 6.1 percent of cancer cases were linked to a lack of fruit and vegetables, 4.9 percent to occupation, 4.6 percent to alcohol, 4.1 percent to overweight and obesity and 3.5 percent to excessive sun exposure and tanning beds.

In women, 6.9 percent of cancer cases were linked to overweight and obesity, 3.7 percent to infections such as HPV, 3.6 percent to excessive sun exposure and tanning beds, 3.4 percent to lack of fruit and vegetables and 3.3 percent to alcohol, the research said.

Copyright United Press International 2012

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Walnuts slow growth of prostate cancer in mice, UC Davis research shows

Bill Lindelof
The Sacramento Bee, Calif.

01-26-12

Jan. 25–New research in mice by UC Davis shows that walnuts slow the growth of prostate cancer.

Mice fed a diet with walnuts had smaller, slower growing tumors, the researchers reported in the current issue of the British Journal of Nutrition.

A low-fat diet is often recommended for reducing the risk for developing or slowing growth of prostate cancer. However, the UC Davis study suggests that not eating walnuts may be a mistake.

Walnuts are rich in omega-3 polyunsaturated fats, antioxidants and other plant chemicals. Eschewing walnuts may mean foregoing the protective effects of walnuts on tumor growth.

One in six men will be diagnosed with prostate cancer, usually later in life. One in 36 will die from the disease because most tumors do not spread beyond the local site, according to the National Cancer Institute.

“Our findings suggest that eating a diet containing walnuts may slow prostate tumor growth so that the tumor remains inside the prostate capsule,” said Paul Davis, research nutritionist in the Department of Nutrition and researcher with the UC Davis Cancer Center. “If proven applicable in humans, men with prostate cancer could die of other causes — hopefully old age.”

The research was funded by the California Walnut Board, according to a UC Davis Cancer Center press release.

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The onset of cognitive decline begins at 45

NewsRx.com

01-20-12

Increased life expectancy implies fundamental changes in the composition of populations, with a significant rise in the number of elderly people. These changes are likely to have a massive influence on the life of individuals and on society in general. Abundant evidence has clearly established an inverse association between age and cognitive performance, but the age at which cognitive decline begins is much debated. Recent studies concluded that there was little evidence of cognitive decline before the age of 60 (see also Inserm Institut national de la sante et de la recherche medicale).

However, clinical studies demonstrate a correlation between the presence of amyloid plaques in the brain and the severity of cognitive decline. It would seem that these amyloid plaques are found in the brains of young adults.

Few assessments of the effect of age on cognitive decline use data that spans over several years. This was the specific objective of the study led by researchers from Inserm and the University College London.

As part of the Whitehall II cohort study, medical data was extracted for 5,198 men and 2,192 women, aged between 45 and 70 at the beginning of the study, monitored over a 10-year period. The cognitive functions of the participants were evaluated three times over this time. Individual tests were used to assess memory, vocabulary, reasoning and verbal fluency.

The results show that cognitive performance (apart from the vocabulary tests) declines with age and more rapidly so as the individual’s age increases. The decline is significant in each age group.

For example, during the period studied, reasoning scores decreased by 3.6 % for men aged between 45 and 49, and 9.6 % for those aged between 65 and 70. The corresponding figures for women stood at 3.6% and 7.4% respectively.

The authors underline that evidence pointing to cognitive decline before the age of 60 has significant consequences.

“Determining the age at which cognitive decline begins is important since behavioural or pharmacological interventions designed to change cognitive aging trajectories are likely to be more effective if they are applied from the onset of decline.” underlines Archana Singh-Manoux.

“As life expectancy continues to increase, understanding the correlation between cognitive decline and age is one of the challenges of the 21st Century” she adds.

Keywords: Proteins, Inserm Institut national de la sante et de la recherche medicale, Inserm (Institut national de la sante et de la recherche medicale).

This article was prepared by Biotech Week editors from staff and other reports. Copyright 2012, Biotech Week via NewsRx.com.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2012, Biotech Week via NewsRx.com

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Reasons to Have a Cup of Tea

Barbara Quinn
The Monterey County Herald, Calif.

01-13-12

“There is no trouble so great or grave that cannot be much diminished by a nice cup of tea,” wrote Bernard-Paul Heroux. (http://www.quotegarden.com/tea.html)

What is it about a cup of hot tea that is so…soothing? I happen to think it’s the warmth that emanates from pretty tea cups. But scientists credit a host of naturally-occurring compounds in tea with beneficial health effects.

All tea comes from the same plant: Camellia sinensis. And over the centuries as this plant grew in the sun, says the USDA Agricultural Research Service, it formed chemicals called “polyphenols” to protect it from the elements. Polyphenols are family to “flavonoids” – health-promoting antioxidant substances found in many fruits and vegetables.

When tea leaves are processed into the various forms of tea, the flavonoid content changes, say researchers. Green tea, for example, contains more simple antioxidant flavonoids while black tea contains more complex varieties.

Green, black and oolong teas are all from the same C. sinensis plant…just processed differently. Green tea is minimally fermented – the process of exposing to air and drying. Black tea is maximally fermented. And oolong tea is somewhere in the middle.

Beside the fact that tea contains zero calories and soothes your soul, here are some other compelling reasons to enjoy a cup of tea:

Curb food cravings. “Afternoon tea” was supposedly started by the 7th Duchess of Bedford (England) to keep her hunger pangs at bay between lunch and dinner. And (from personal experience) it also seems to work in those munch-prone hours after dinner.

Lower cholesterol. Tea drinking has shown to help lower “bad” LDL cholesterol levels in some studies. Powerful antioxidant substances in tea are believed to be the reason.

Fight infections. Several compounds have been found in black and green teas that work like antibiotics to fight off the bad bugs that make us sick.

Prevent halitosis (bad breath). Swish with tea to suppress foul mouth odor? Researchers at the University of Illinois found that some of the polyphenols in tea inhibit the growth of bacteria in the mouth that can cause this unpleasant smell.

What about herbal teas? While not officially “tea” from the Camellia sinensis plant, infusions from the leaves of other plants may have their own benefits, according to scientists at Tufts University.

Chamomile and peppermint teas, for example, appear to have infection-fighting capabilities. Peppermint tea is also rich in antioxidants that help fight against cancer growth. And a clinical trial with hibiscus tea showed a blood pressure lowering effect in volunteers who drank 3 cups a day for six weeks.

How to make a perfect cup of tea? Here are some key steps, according to Cindy Bigelow, whose grandmother invented Constant Comment:

-Start with cold fresh water every time, not the leftover in your tea kettle. “It’s the oxygen in the water that opens up the tea leaf for full flavor extraction,” says Bigelow.

-For black and oolong teas, bring the water to a rolling boil and then pour over leaves or tea bag. Steep for 1 or 2 minutes.

-Green teas are more delicate. Use water that has just begun to boil and steep for 3 to 4 minutes.

-Do not, do not squeeze your teabag into your tea, says Bigelow. This releases bitter tannins that destroy flavor.

Lastly, “Remember the tea kettle,” someone once said.”It is always up to its neck in water, yet it still sings!”

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Study: Why coffee reduces diabetes risk

United Press International

01-12-12

Drinking several cups of coffee daily reduces type 2 diabetes risk because it inhibits a substance linked to the disease, scientists in China suggest.

Ling Zheng, Kun Huang and colleagues say previous studies show people who drink four or more cups of coffee daily have a 50 percent lower risk of type 2 diabetes. Every additional cup of coffee decreases the risk by almost 7 percent, the researchers said.

Scientists said the misfolding of the substance human islet amyloid polypeptide has been increasingly considered a pathogenic process in type 2 diabetes.

The study, published in the Journal of Agricultural & Food Chemistry, identified two categories of compounds in coffee that significantly inhibited human islet amyloid polypeptide.

The findings suggest this explains why coffee drinkers show a lower risk for developing diabetes.

“A beneficial effect may thus be expected for a regular coffee drinker,” the researchers concluded.

Copyright United Press International 2012

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Poor diet of mom-to-be linked to diabetes

United Press International

01-10-12

In both rats and humans, what a mother-to-be eats impacts how her child stores fats later, researchers in Britain said.

Professor Anne Willis of the Medical Research Council Toxicology Unit at the University of Leicester said storing fats in the right areas of the body is important because otherwise they can accumulate in places like the liver and muscle where they are more likely to lead to disease.

“One of the ways that our bodies cope with a rich modern western diet is by storing excess calories in fat cells,” Willis said in a statement. “When these cells aren’t able to absorb the excess then fats get deposited in other places, like the liver, where they are much more dangerous and can lead to type 2 diabetes.”

The research team found that this process is controlled by a molecule called miR-483-3p. Willis and colleagues found that miR-483-3p was produced at higher levels in individuals who had experienced a poor diet in their mother’s wombs than those who were better nourished.

When pregnant rats were fed low protein diets their offspring had higher levels of miR-483-3p. This led to them developing smaller fat cells and left them less able to store fats in adulthood. These rats were less likely to get fat when fed a high calorie diet but were at a higher risk of developing diabetes

The findings were published in the journal Cell Death and Differentiation.

Copyright United Press International 2012

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